If you are using Active Sky, learn to read the Winds Aloft figures -- careful choice of cruising altitude can make a big difference to your ground speed and range. (Don't forget to factor in the wind speed and direction when calculating range in miles - aircraft range is normally specified as endurance in hours at a specified power level)
Make a series of test flights to determine your exact fuel burn in all phases of flight. Do this by using one tank for the test and the other tank for the rest of the flight (e.g. for cruise fuel burn, taxi/take off/climb on the left tank. Then fly exactly an hour cruise on the right tank, switch back to the left tank for descent and landing. And so on.). Don't forget to measure the contents of the test tank before and after!
Don't rely on the built in flight planner for range/speed calculations - it's not that accurate. Use your own numbers as calculated above
FS aircraft don't have the option of ferry tanks. Where you would need them RW to complete a flight, it's considered acceptable to adjust your fuel levels in flight in FS. Figure 10% over MAUW for calculations.
This is your one stop shop for freeware scenery:
http://walhalla.mine.nu/fs2004.php